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. 2016 May;18(3):395–406. doi: 10.1016/j.jmoldx.2015.12.006

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© 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

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Expression analysis between radical prostatectomies (RPs) and biopsy (BX). A: High concordance of gene expression levels between BX and RP (r = 0.96). B: Differential expression analysis using median fold difference (MFD) shows that the MFD between RP tumor and RP benign contralateral, and BX tumor and BX benign contralateral, is consistent in terms of directionality. C: The genes differentially expressed between tumor and benign contralateral in BX and RP are overlapping with genes differentially expressed between tumor and benign contralateral in external public data sets. Statistical significance was assessed via bootstrapping (P < 0.05).