Figure 6.

Functional analysis of the field effect signature. A: The field effect signature is distinct from prostate cancer genes differentially expressed between tumor and benign tissues (Memorial Sloan Kettering Cancer Center and German Cancer Research Center).24, 25B: Functional enrichment analysis reveals that the field effect signature is highly enriched with gene categories of RNA splicing, ubiquitin-dependent catabolism, epigenetics, and cellular transport. C: Functional interaction networks generated by STRING of 75 transcription factors whose targets are enriched in the field effect signature on the basis of a chromatin immunoprecipitation enrichment analysis tool.²⁷D: Density plots of Pearson's correlation between field effect signature and ERG and ETV1 genes, suggesting that field effect is independent of ERG and ETS.