Table 3:
In vitro production of IFN-γ and IL-12p70 levels following stimulation in two brothers and one girl with MSMD and healthy control subjects
| Cytokine | Stimulators | Patient 1 | Patient 2 | Patient 3 | Healthy control-1 | Healthy control-2 |
|---|---|---|---|---|---|---|
| IFN-γ (pg/ml) | Medium | 0 | 21.5 | 54 | 0 | 26 |
| BCG | 470.7 | 261 | 39 | 373 | 503 | |
| BCG +rhIL-12 | 1126.6 | 736 | 68 | 4490 | 3675 | |
| SI* | 2.4 | 2.8 | 1.74 | 12 | 7.3 | |
| IL-12 (p70) (pg/ml) | Medium | 16.3 | 50.8 | 0 | 55.4 | 92.4 |
| BCG | 237.9 | 95.9 | 161.7 | 178 | 177.8 | |
| BCG + rhIFN-γ | 2960 | 1186 | 647.4 | 2212 | 3247 | |
| SI* | 12.4 | 12.3 | 4 | 12.4 | 18.2 |
*
Stimulation index (BCG+cytokine/BCG)