Table 5.
Incidence of hypertension by serum uric acid quartile in normal-eGFR subjects
| Model | N (%) | Hazard ratio | 95 % CI | P-value |
|---|---|---|---|---|
| Model A: unadjusted | ||||
| Quartile 1 | 844 (24.5 %) | – | – | 0.000 |
| Quartile 2 | 872 (25.4 %) | 1.738 | 1.321–2.287 | 0.000 |
| Quartile 3 | 855 (24.9 %) | 2.166 | 1.666–2.815 | 0.000 |
| Quartile 4 | 867 (25.2 %) | 3.065 | 2.386–3.937 | 0.000 |
| SUA as a continuous variable (μmol/L) | 3438 | 2.061 | 1.758–2.416 | 0.000 |
| Model B: model A adjusted for age and sex | ||||
| Quartile 1 | – | – | – | 0.000 |
| Quartile 2 | – | 1.761 | 1.331–2.329 | 0.000 |
| Quartile 3 | – | 2.305 | 1.751–3.035 | 0.000 |
| Quartile 4 | – | 3.320 | 2.535–4.347 | 0.000 |
| SUA as a continuous variable (μmol/L) | – | 2.040 | 1.739–2.392 | 0.000 |
| Model C: model B further adjusted for other confounders | ||||
| Quartile 1 | – | – | – | 0.000 |
| Quartile 2 | – | 1.662 | 1.261–2.190 | 0.000 |
| Quartile 3 | – | 2.028 | 1.552–2.649 | 0.000 |
| Quartile 4 | – | 2.747 | 2.115–3.566 | 0.000 |
| SUA as a continuous variable (μmol/L) | – | 1.807 | 1.519–2.150 | 0.000 |
Model C was further adjusted for BMI, TG, eGFR, blood urea nitrogen, serum creatinine, plasma total protein, globulin, alanine aminotransferase, and direct bilirubin
Quartiles based on serum uric acid levels: 1, <4.66 mg/dl; 2, 4.66–5.53 mg/dl; 3, 5.53–6.46 mg/dl; 4, ≥6.46 mg/dl