Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 30;16:35. doi: 10.1186/s12935-016-0310-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Hayashi et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 6 — Effective inhibition of mesothelioma cell growth in vivo. A Combination effects of YS110 and PMX were examined using xenograft models with JMN cells transplantation subcutaneously. The weight of tumors treated with YS110 was insignificantly reduced but PMX treatment induced a significantly reduced tumor weight (*p < 0.05). A combination of YS110 and PMX treatment reduced tumor weight compared with the weight of tumors with YS110 single treatment and PMX single treatment synergistically (**p < 0.05). B Combination effects of tumor growth in vivo were examined using a measurement of MIB-1 index histologically. MIB-1 index was significantly reduced with YS110 or PMX single treatment compared with control IgG treatment (*p < 0.05). The MIB-1 index after combinatory treatment with YS110 and PMX was significantly reduced compared with YS110 or PMX single treatment (**p < 0.05). C Sarcomatous mesothelioma is shown in HE staining (a) and stained with anti-CD26 polyclonal antibody (R&D) (b) MIB-1 index was measured by immunohistochemistry using the anti-Ki-67 monoclonal antibody (DAKO, clone MIB-1). Staining of Ki-67 antigens in nucleus is seen in tumors treated with control IgG (c), YS110 (d), and both YS110 and PMX (e). The number of Ki-67 positive nucleus was reduced after combinatory treatment of YS110 and PMX and the necrotic area is indicated by an asterisk (e)