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. 2016 Apr 30;15:30. doi: 10.1186/s12943-016-0515-5

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© Cheng et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — TIMP-1 is highly expressed in breast cancer and is expressed at particularly high levels in TNBC. a TIMP-1 gene-centric expression analysis using Oncomine. TIMP-1 is significantly overexpressed in invasive breast cancer tissue compared with normal breast tissue in samples from the TCGA Breast cancer microarray database (p = 2.18E-14). b Similar results were observed in the Sorlie Breast 2 microarray data (p = 2.15E-5). c The expression level of TIMP-1 mRNA in various breast cancer cell lines was evaluated using Real-time PCR. The data are presented as the mean ± SD. d TIMP-1 protein levels in cell culture medium were detected using ELISA assays. The results demonstrated that TNBC cells express higher levels of TIMP-1 compared with non-TNBC cells. The data are presented as the mean ± SD