Table 3.

Univariate and multivariate analyses of prognostic factors for overall survival in gastric cancer

	Univariate analysis			Multivariate analysis
	HR	p>|z|	95% CI	HR	p>|z|	95% CI
NNMT expression
High vs Low	1.894	<0.001*	1.509-2.378	1.446	0.028*	1.041-2.065
Gender
Male vs Female	0.930	0.559	0.730-1.185
Age
>60 years vs ≤60 years	1.463	0.001*	1.169-1.831	0.434	0.878	0.633-1.217
Histological type
Tubular vs Hybrid vs Mucinous vs Signet ring cell vs othersa	0.929	0.257	0.817-1.055
Differentiation
High vs moderate vs low vs othersb	1.397	<0.001*	1.137-1.716	1.106	0.575	0.778-1.572
Primary tumor size
T4 vs T3 vs T2 and T1 vs Tis	2.017	<0.001*	1.747-2.329	1.436	0.014*	1.075-1.918
Lymph node metastasis
N3 vs N2 vs N1 vs N0	1.702	<0.001*	1.554-1.865	1.288	0.004*	1.082-1.532
Distant metastasis
M1 vs M0	3.745	<0.001*	2.641-5.312	3.195	<0.001*	1.697-6.013
TNM stage
IV vs III vs II vs and I	2.244	<0.001*	1.979-2.545	1.400	0.054	0.995-1.969
Preoperative CEA, ng/ml
>5 versus ≤5	2.403	<0.001*	1.763-3.274	1.772	0.003*	1.216-2.582
Preoperative CA199, U/ml
>37 versus ≤37	2.570	<0.001*	1.806-3.649	1.524	0.051	0.998-2.326

^* P<0.05;

^aothers: papillary adenocarcinoma, 4 cases; adeno-squamous carcinoma, 4 cases; squamous cell carcinoma, 2 cases; undifferentiated carcinoma, 2 cases; neuroendocrine carcinoma, 1 case.

^bothers: tumors other than tubular or papillary adenocarcinomas.