Supplementary Table 2.

Downregulated genes at regions exposed to high stress (2-fold change threshold).

Fold change	Symbol	Definition / (Chromosomal Location)	p value
2.11	SIGLEC5	Sialic acid binding Ig-like lectin 5 (19)	0.042
2.30	UBASH3A	Ubiquitin associated and SH3 domain-containing, A (21)	0.049
4.13	FCAMR	Fc receptor, IgA, IgM, high affinity (1)	0.046
2.18	LOC349236	Chromosome 9 open reading frame 164 (9)	0.004
2.11	CYP3A43	Cytochrome P450, family 3, subfamily A, polypeptide 43 (7)	0.001
2.08	TRIM69	Tripartite motif-containing 69 (15)	0.037
2.03	CD80	CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) (3)	0.009
4.04	CHI3L2	Chitinase 3-like 2 (1)	0.034
2.39	OR5B21	Olfactory receptor, family 5, subfamily B, member 21 (11)	0.005
2.24	MARCO	Macrophage receptor with collagenous structure (2)	0.023
2.76	LOC158830	Similar to Ab2-183 (X)	0.041
2.25	HGD	Homogentisate 1,2-dioxygenase (homogentisate oxidase) (3)	0.021
2.14	TTN	Titin (2)	0.009
2.42	DPPA4	Developmental pluripotency associated 4 (3)	0.044
2.11	TAP2	Transporter 2, ATP-binding cassette, sub-family B (6)	0.045
2.05	C7orf16	Chromosome 7 open reading frame 16 (7)	0.031
2.40	TRAF3IP3	TRAF3 interacting protein 3 (1)	0.043
2.24	ELF3	E74-like factor 3 (ets domain transcription factor) (1)	0.034
2.58	TLR10	Toll-like receptor 10 (4)	0.049
2.39	RAB26	RAB26, member RAS oncogene family (16)	0.025
2.43	SCML4	Sex comb on midleg-like4 (Drosophila) (6)	0.034
2.05	SLC12A3	Solute carrier family 12 (sodium/chloride transporters) (16)	0.028
2.13	MCOLN2	Mucolipin 2 (1)	0.022
2.26	ANGPTL6	Angiopoietin-like 6 (19)	0.022
2.38	RAB39B	RAB39B, member RAS oncogene family (X)	0.044
4.24	FLJ40919	Hypothetical protein FLJ40919 (13)	0.042
2.28	CPLX3	complexin 3 (15)	0.004
2.77	C6orf105	Chromosome 6 open reading frame 105 (6)	0.016
2.31	RP11-450P7.3	Kelch-like 34 (Drosophila) (X)	0.033
2.11	TRIM14	Tripartite motif-containing 14 (9)	0.047
2.10	MGC40069	Hypothetical protein MGC40069	0.033
2.78	CCL22	Chemokine (C-C motif) ligand 22 (16)	0.017
2.01	TM7SF2	Transmembrane 7 superfamily member 2 (11)	0.035
2.33	CCL20	Chemokine (C-C motif) ligand 20 (2)	0.040
2.47	CCR6	Chemokine (C-C motif) ligand 6 (6)	0.034
2.05	EMR2	EGF-like module containing, mucin-like hormone rec (19)	0.019
2.83	KIAA1189	KIAA1189 (2)	0.047
2.48	KIR3DL2	Killer cell immunoglobulin-like receptor (19)	0.012
2.05	C9orf128	Chromosome 9 open reading frame 128 (9)	0.048
2.11	ATP2A3	ATPase, Ca + + transporting, ubiquitous (17)	0.048
2.26	ANKRD55	Ankyrin repeat domain 55 (5)	0.046
2.97	TXK	TXK tyrosine kinase (4)	0.041
2.75	TMEM16J	Transmembrane protein 16J (11)	0.011
2.64	FCRL3	Fc receptor-like 3 (1)	0.009
2.76	KEL	Kell blood group, metallo-endopeptidase (7)	0.040
2.07	C20orf174	Chromosome 20 open reading frame 174 (20)	0.042
2.63	CXADR	Coxsackie virus and adenovirus receptor (21)	0.044
2.06	FLJ43752	FLJ43752 protein (6)	0.001
2.91	ZAP70	Zeta-chain (TCR) associated protein kinase 70 kDa (2)	0.028
3.03	IBSP	Integrin-binding sialoprotein (4)	0.022
2.62	TDO2	Tryptophan 2,3-dioxygenase (4)	0.043
2.78	FCRL3	Fc receptor-like 3 (1)	0.047
2.37	FLJ11795	FLJ11795 protein (5)	0.049
2.33	COL4A3	Collagen, Type IV, alpha 3 (2)	0.033

Highly significant genes appear in bold.