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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2016 Jan 22;95(2):791–799. doi: 10.1016/j.ijrobp.2016.01.025

Figure 3.

Figure 3

Ectopic expression of miR-33a inhibits HDL-induced radiosensitization. (A, B) Overexpression of miR-33a via transfection of miR-33 mimic in SUM149 and KPL4 cells resulted in lower ABCA1 expression than non-target transfection. (C, D) Clonogenic survival assays of miR-33a–overexpressing SUM149 and KPL4 breast cancer cells irradiated at different doses (x axis) with or without HDL pretreatment. HDL pretreatment comprised incubation with HDL 10 μg/mL for 24 hours. After irradiation, colonies were allowed to form for 14 days. The surviving fractions at each dose of radiation are shown. Data represented as mean +/− standard deviation. Significant differences are shown as follows: *, P < 0.05 for unpaired 2-tailed Student’s t-test (n = 3).