Table 1.
Baseline Characteristics
| Lumpectomy & External Radiation |
Mastectomy Alone | Mastectomy & Reconstruction |
Lumpectomy & Brachytherapy |
Lumpectomy Alone |
All Patients | P | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N=27,869 | N=18,356 | N=1488 | N=1455 | N=6159 | N=55,327 | ||||||||
| Patient and Treatment Factors | |||||||||||||
| Age | |||||||||||||
| 66–69 | 7615 | 27.3% | 3460 | 18.8% | 690 | 46.4% | 385 | 26.5% | 545 | 8.8% | 12695 | 22.9% | <0.001 |
| 70–74 | 8214 | 29.5% | 4535 | 24.7% | 469 | 31.5% | 410 | 28.2% | 774 | 12.6% | 14402 | 26.0% | |
| 75–79 | 6919 | 24.8% | 4664 | 25.4% | 236 | 15.9% | 349 | 24.0% | 1159 | 18.8% | 13327 | 24.1% | |
| 80–84 | 3908 | 14.0% | 3543 | 19.3% | 63 | 4.2% | 221 | 15.2% | 1608 | 26.1% | 9343 | 16.9% | |
| 85+ | 1213 | 4.4% | 2154 | 11.7% | 30 | 2.0% | 90 | 6.2% | 2073 | 33.7% | 5560 | 10.0% | |
| Race | |||||||||||||
| White | 25002 | 89.7% | 15778 | 86.0% | 1368 | 91.9% | 1329 | 91.3% | 5495 | 89.2% | 48972 | 88.5% | <0.001 |
| Black | 1515 | 5.4% | 1454 | 7.9% | 74 | 5.0% | 75 | 5.2% | 400 | 6.5% | 3518 | 6.4% | |
| Other/Unknown | 1352 | 4.9% | 1124 | 6.1% | 46 | 3.1% | 51 | 3.5% | 264 | 4.3% | 2837 | 5.1% | |
| Charlson Comorbidity Index | |||||||||||||
| 0 | 18694 | 67.1% | 10612 | 57.8% | 1067 | 71.7% | 971 | 66.7% | 3365 | 54.6% | 34709 | 62.7% | <0.001 |
| 1 | 6110 | 21.9% | 4599 | 25.1% | 298 | 20.0% | 337 | 23.2% | 1542 | 25.0% | 12886 | 23.3% | |
| ≥2 | 2585 | 9.3% | 2529 | 13.8% | 100 | 6.7% | 147 | 10.1% | 1030 | 16.7% | 6391 | 11.6% | |
| Incomplete | 480 | 1.7% | 616 | 3.4% | 23 | 1.5% | 0 | 0.0% | 222 | 3.6% | 1341 | 2.4% | |
| Chemotherapy | |||||||||||||
| No | 23486 | 84.4 | 15365 | 83.8 | 1130 | 75.9 | 1347 | 92.6 | 5947 | 96.6 | 47275 | 85.5% | <0.001 |
| Yes | 4356 | 15.7 | 2978 | 16.2 | 358 | 24.1 | 108 | 7.4 | 209 | 3.4 | 8009 | 14.5% | |
| Year of Diagnosis | |||||||||||||
| 2000 | 2777 | 10.0% | 2262 | 12.3% | <150 | <9% | <20 | <2% | 612 | 9.9% | 5795 | 10.5% | <0.001 |
| 2001 | 2978 | 10.7% | 2502 | 13.6% | <170 | <11% | <11 | <1% | 640 | 10.4% | 6283 | 11.4% | |
| 2002 | 3125 | 11.2% | 2262 | 12.3% | 150 | 10.1% | 38 | 2.6% | 653 | 10.6% | 6228 | 11.3% | |
| 2003 | 3223 | 11.6% | 2082 | 11.3% | 152 | 10.2% | 87 | 6.0% | 577 | 9.4% | 6121 | 11.1% | |
| 2004 | 3233 | 11.6% | 2015 | 11.0% | 166 | 11.2% | 144 | 9.9% | 690 | 11.2% | 6248 | 11.3% | |
| 2005 | 3062 | 11.0% | 1864 | 10.2% | 150 | 10.1% | 187 | 12.9% | 740 | 12.0% | 6003 | 10.9% | |
| 2006 | 3182 | 11.4% | 1763 | 9.6% | 148 | 9.9% | 263 | 18.1% | 779 | 12.6% | 6135 | 11.1% | |
| 2007 | 3123 | 11.2% | 1835 | 10.0% | 209 | 14.0% | 334 | 23.0% | 733 | 11.9% | 6234 | 11.3% | |
| 2008 | 3166 | 11.4% | 1771 | 9.6% | 227 | 15.3% | 381 | 26.2% | 735 | 11.9% | 6280 | 11.4% | |
| Tumor Factors | |||||||||||||
| Tumor Size | |||||||||||||
| T1 (0.0 – 2.0 cm) | 22995 | 82.5% | 11866 | 64.6% | 1026 | 69.0% | 1312 | 90.2% | 4898 | 79.5% | 42097 | 76.1% | <0.001 |
| T2 (2.1 – 5.0 cm) | 4676 | 16.8% | 6326 | 34.5% | 443 | 29.8% | 132 | 9.1% | 1202 | 19.5% | 12779 | 23.1% | |
| Not specified | 198 | 0.7% | 164 | 0.9% | 19 | 1.3% | 11 | 0.8% | 59 | 1.0% | 451 | 0.8% | |
| Nodal Status | |||||||||||||
| Pathological N0 | 21386 | 76.7% | 13493 | 73.5% | 1192 | 80.1% | 1301 | 89.4% | 2737 | 44.4% | 40109 | 72.5% | <0.001 |
| Clinical N0 | 2524 | 9.1% | 1184 | 6.5% | 46 | 3.1% | 95 | 6.5% | 3090 | 50.2% | 6939 | 12.5% | |
| Pathologic N1 | 3959 | 14.2% | 3679 | 20.0% | 250 | 16.8% | 59 | 4.1% | 332 | 5.4% | 8279 | 15.0% | |
| Histology | |||||||||||||
| Ductal, tubular, mucinous | 20920 | 75.1% | 12653 | 68.9% | 884 | 59.4% | 1156 | 79.5% | 4546 | 73.8% | 40159 | 72.6% | <0.001 |
| Lobular | 2282 | 8.2% | 1815 | 9.9% | 184 | 12.4% | 71 | 4.9% | 480 | 7.8% | 4832 | 8.7% | |
| Other invasive | 3959 | 14.2% | 2804 | 15.3% | 260 | 17.5% | 184 | 12.6% | 923 | 15.0% | 8130 | 14.7% | |
| DCIS | 708 | 2.5% | 1084 | 5.9% | 160 | 10.8% | 44 | 3.0% | 210 | 3.4% | 2206 | 4.0% | |
| Grade | |||||||||||||
| Low-intermediate | 19933 | 71.5% | 11438 | 62.3% | 925 | 62.2% | 1175 | 80.8% | 4548 | 73.8% | 38019 | 68.7% | <0.001 |
| High | 6197 | 22.2% | 5249 | 28.6% | 428 | 28.8% | 223 | 15.3% | 1069 | 17.4% | 13166 | 23.8% | |
| Other/unknown | 1739 | 6.2% | 1669 | 9.1% | 135 | 9.1% | 57 | 3.9% | 542 | 8.8% | 4142 | 7.5% | |
| Estrogen Receptor Status | |||||||||||||
| ER+ | 22136 | 79.4% | 12722 | 69.3% | 1086 | 73.0% | 1245 | 85.6% | 4717 | 76.6% | 41906 | 75.7% | <0.001 |
| ER- | 3291 | 11.8% | 2568 | 14.0% | 228 | 15.3% | 108 | 7.4% | 466 | 7.6% | 6661 | 12.0% | |
| Unspecified | 2442 | 8.8% | 3066 | 16.7% | 174 | 11.7% | 102 | 7.0% | 976 | 15.8% | 6760 | 12.2% | |
| Area-level Factors | |||||||||||||
| Type of Patient Residence | |||||||||||||
| Urban | 25823 | 92.7% | 15477 | 84.3% | 1373 | 92.3% | 1369 | 94.1% | 5550 | 90.1% | 49592 | 89.6% | <0.001 |
| Rural | >2025 | >5 | 2879 | 15.7% | 115 | 7.7% | 86 | 5.9% | 609 | 9.9% | >5725 | >5 | |
| Unknown | <11 | <5 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | <11 | <5 | |
| Density of Surgeons | |||||||||||||
| Highest Quartile | 6125 | 22.0% | 5598 | 30.5% | 348 | 23.4% | 351 | 24.1% | 1413 | 22.9% | 13835 | 25.0% | <0.001 |
| Second Quartile | 7222 | 25.9% | 4542 | 24.7% | 364 | 24.5% | 414 | 28.5% | 1711 | 27.8% | 14253 | 25.8% | |
| Third Quartile | 7184 | 25.8% | 3942 | 21.5% | 375 | 25.2% | 323 | 22.2% | 1569 | 25.5% | 13393 | 24.2% | |
| Fourth Quartile | 7338 | 26.3% | 4274 | 23.3% | 401 | 26.9% | 367 | 25.2% | 1466 | 23.8% | 13846 | 25.0% | |
| Density of Radiation Oncologists | |||||||||||||
| Highest Quartile | 5552 | 19.9% | 6088 | 33.2% | 328 | 22.0% | 334 | 23.0% | 1495 | 24.3% | 13797 | 24.9% | <0.001 |
| Second Quartile | 7416 | 26.6% | 4167 | 22.7% | 393 | 26.4% | 458 | 31.5% | 1582 | 25.7% | 14016 | 25.3% | |
| Third Quartile | 7600 | 27.3% | 3764 | 20.5% | 382 | 25.7% | 298 | 20.5% | 1642 | 26.7% | 13686 | 24.7% | |
| Fourth Quartile | 7301 | 26.2% | 4337 | 23.6% | 385 | 25.9% | 365 | 25.1% | 1440 | 23.4% | 13828 | 25.0% | |
| Residents with Some College Education | |||||||||||||
| 1st Quartile (0 – 8.1%) | 8117 | 29.1% | 3409 | 18.6% | 517 | 34.7% | 490 | 33.7% | 1545 | 25.1% | 14078 | 25.4% | <0.001 |
| 2nd Quartile (8.2% – 14.4%) | 7190 | 25.8% | 4108 | 22.4% | 387 | 26.0% | 375 | 25.8% | 1527 | 24.8% | 13587 | 24.6% | |
| 3rd Quartile (14.5 – 24.0%) | 6755 | 24.2% | 4979 | 27.1% | 294 | 19.8% | 308 | 21.2% | 1500 | 24.4% | 13836 | 25.0% | |
| 4th Quartile (>24.1%) | 5807 | 20.8% | 5860 | 31.9% | 290 | 19.5% | 282 | 19.4% | 1587 | 25.8% | 13826 | 25.0% | |
| Income Level | |||||||||||||
| 1st Quartile ($0 – $35,453) | 5672 | 20.4% | 6069 | 33.1% | 279 | 18.8% | 258 | 17.7% | 1556 | 25.3% | 13834 | 25.0% | <0.001 |
| 2nd Quartile ($35,454 – $46,559) | 6619 | 23.8% | 4967 | 27.1% | 317 | 21.3% | 370 | 25.4% | 1557 | 25.3% | 13830 | 25.0% | |
| 3rd Quartile ($46,560 – $62,311) | 7451 | 26.7% | 4135 | 22.5% | 371 | 24.9% | 369 | 25.4% | 1505 | 24.4% | 13831 | 25.0% | |
| 4th Quartile (>$62,312) | 8127 | 29.2% | 3185 | 17.4% | 521 | 35.0% | 458 | 31.5% | 1541 | 25.0% | 13832 | 25.0% | |
Abbreviations: DCIS (ductal carcinoma in situ), ER (estrogen receptor). Cell sizes < 11 have been suppressed in accordance with guidelines from SEER-Medicare.