. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: IEEE Trans Biomed Eng. 2015 Oct 30;63(7):1473–1482. doi: 10.1109/TBME.2015.2496233

TABLE II.

Comparison with state-of-the-art methods using multiple templates in AD vs. NC and pMCI vs. sMCI classification

Method	Feature Type	Classifier	AD vs. NC			pMCI vs. sMCI
Method	Feature Type	Classifier	ACC (%)	SEN (%)	SPE (%)	ACC (%)	SEN (%)	SPE (%)
Koikkalainen et al. [19]	TBM	Linear regression	86.00	81.00	91.00	72.10	77.00	71.00
Wolz et al. [8]	TBM	Linear discriminant analysis	87.00	84.00	90.00	64.00	65.00	62.00
Min et al. [31]	Data-Driven ROI GM	SVM	91.64	88.56	93.85	72.41	72.12	72.58
Min et al. [34]	Data-Driven ROI GM	SVM	90.69	87.56	93.01	73.69	76.44	70.76
Liu et al. [32]	Data-Driven ROI GM	SVM ensemble	92.51	92.89	88.33	78.88	85.45	76.06
ISML (ours)	Data-Driven ROI GM	SVM ensemble	93.83	92.78	95.69	80.90	85.95	78.41