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Transdermal cannabidiol (CBD) reduced monoarthritis-induced hind paw heat hypersensitivity. (A) Transdermal CBD significantly increased heat paw withdrawal latency in rats with monoarthritis, (B) but had no effect in naïve rats (*p < 0.01 vs. day 3, one-way ANOVA). (C, D) In the open-field test, transdermal CBD exerts no detectable effect on times spent in spontaneous exploratory activity or resting. (n = 5 per group and CBD dose)
