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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Addict Biol. 2015 Oct 30;22(1):172–183. doi: 10.1111/adb.12316

Figure 5.

Figure 5

Experiment 3. (A) Schematic representation of injection sites in the DMS (from 0.0 mm to −4.8 mm AP from bregma, adapted from Paxinos and Watson, 2005). The location of the most ventral point of the cannula tract is depicted for rats exposed to the saline (circles) and METH (diamonds) paired-contexts. (B) Mean (± SEM) number of lever presses during extinction and negative feedback tests when rats were tested in the Saline Context after infusion of either vehicle or the A2A antagonist ZM241385 in Experiment 3. Preference for the non-devalued lever is shown in these tests and this preference was unaffected by ZM241385. (C) Mean (± SEM) number of lever presses during extinction and negative feedback tests when rats were tested in the METH Context after infusion of either vehicle or the A2A antagonist ZM241385. No effect of outcome devaluation was observed in the Meth context except when ZM241385 was infused during the negative feedback test indicating that sensitivity to negative feedback was restored in this condition.