Table 3.

Risk of Incident Skin Cancer According to History of Severe Sunburn at Only 1 Body Site in the Nurses' Health Study (1982–2010) and the Health Professionals Follow-up Study (1992–2010)

Skin Cancer Type and Site of Sunburn	Women						Men
	No. of Cases	No. of Person-Years	Age-Adjusted		Multivariate-Adjusteda		No. of Cases	No. of Person-Years	Age-Adjusted		Multivariate-Adjusteda
			HR	95% CI	HR	95% CI			HR	95% CI	HR	95% CI
Melanoma
Never sunburned	47	256,347	1.00	Referent	1.00	Referent	11	40,907	1.00	Referent	1.00	Referent
Face/arms only	6	24,026	1.35	0.58, 3.16	1.18	0.51, 2.77	6	10,172	2.18	0.81, 5.90	1.84	0.68, 4.99
Trunk only	62	181,047	1.88	1.28, 2.74	1.65	1.13, 2.41	56	78,853	2.65	1.39, 5.06	2.33	1.22, 4.45
Lower limbs only	4	16,495	1.35	0.48, 3.74	1.15	0.41, 3.20	4	8,530	1.71	0.54, 5.38	1.55	0.49, 4.86
SCC
Never sunburned	107	239,738	1.00	Referent	1.00	Referent	42	35,557	1.00	Referent	1.00	Referent
Face/arms only	14	21,937	1.42	0.81, 2.47	1.31	0.75, 2.28	16	8,196	1.63	0.91, 2.90	1.46	0.82, 2.60
Trunk only	102	166,979	1.40	1.06, 1.83	1.23	0.93, 1.61	118	65,562	1.49	1.05, 2.13	1.34	0.94, 1.90
Lower limbs only	11	15,058	1.65	0.89, 3.07	1.49	0.80, 2.78	11	7,090	1.29	0.66, 2.51	1.19	0.61, 2.31
BCC
Never sunburned	1,311	239,738	1.00	Referent	1.00	Referent	377	35,557	1.00	Referent	1.00	Referent
Face/arms only	154	21,937	1.27	1.08, 1.50	1.19	1.00, 1.40	111	8,196	1.27	1.03, 1.58	1.19	0.96, 1.47
Trunk only	1,111	166,979	1.23	1.14, 1.34	1.12	1.04, 1.22	855	65,562	1.22	1.08, 1.38	1.13	1.00, 1.28
Lower limbs only	113	15,058	1.37	1.13, 1.66	1.26	1.04, 1.53	85	7,090	1.10	0.87, 1.39	1.04	0.82, 1.32

Abbreviations: BCC, basal cell carcinoma; CI, confidence interval; HR, hazard ratio; SCC, squamous cell carcinoma.

^a Results of multivariate analyses were adjusted for the covariates listed in footnote “a” of Table 2.