Table 2.

Estimates of Long-Term Adverse Health Events Following Treatment with Continuous (C) vs. Intermittent (I) Androgen Deprivation Therapy for Patients on S9346

			Logistic Regression Results						Cumulative Incidence Results
	Overall		C		I					5-Year		10-Year
Late Effect	N	%	N	%	N	%	OR (95% CI)	p- value	Total	C	I	C	I	HR*	p- value
Ischemic and Thrombotic Events	153	24	64	20	89	27	0.69 (0.47–0.99)	.05	30	16	23	24	33	0.69	.02
Acute MI	51	8	23	7	28	9	0.82 (0.46–1.47)	.51	10	5	6	8	10	0.80	.42
Ischemic Heart Disease	49	8	18	6	31	10	0.56 (0.31–1.03)	.06	9	5	8	7	12	0.55	.05
Thrombosis (severe)	85	13	37	12	48	15	0.79 (0.5–1.26)	.33	17	9	12	14	17	0.79	.28
Endocrine	273	43	138	44	135	41	1.15 (0.83–1.59)	.39	52	44	41	51	48	1.06	.69
Diabetes	123	19	62	20	61	19	1.12 (0.75–1.67)	.58	24	19	18	23	22	1.08	.69
Diabetes with Sequelae	56	9	26	8	30	9	0.9 (0.52–1.57)	.72	12	8	8	9	10	0.89	.66
Hypercholesterolemia	200	31	99	32	101	31	1.04 (0.74–1.45)	.83	39	30	29	37	37	1.00	1.00
Obesity	42	7	25	8	17	5	1.59 (0.83–3.01)	.16	8	7	5	9	6	1.49	.20
Osteoporosis	135	21	73	23	62	19	1.29 (0.87–1.9)	.20	26	21	18	27	22	1.17	.35
Fracture	99	15	53	17	46	14	1.24 (0.8–1.92)	.34	19	12	10	20	17	1.17	.43
All Bone	182	28	97	31	85	26	1.28 (0.9–1.82)	.17	35	27	23	36	31	1.16	.32
SEXUAL DYSFUNCTION
Organic	36	6	20	6	16	5	1.32 (0.67–2.61)	.42	7	6	5	8	6	1.29	.46
MISCELLANEOUS
Dementia	33	5	22	7	11	3	2.05 (0.97–4.36)	.06	7	5	2	8	4	1.97	.07
Depression	89	14	43	14	46	14	0.94 (0.59–1.47)	.77	18	11	12	15	16	0.92	.69
Acute Kidney Injury	122	19	60	19	62	19	1.02 (0.68–1.52)	.93	30	14	14	21	21	0.98	.91

Regression analyses were conducted separately for each adverse event type in multivariable regression models, adjusting for demographic and stratification factors as covariates as specified in the Methods.

^*Represents the subdistribution hazard ratios based on competing risk regression analyses.