Appendix Table 2.
Logistic Regression Results | Cumulative Incidence Results | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Overall | C | I | 5-Year | 10-Year | |||||||||||
Adverse Health Event | N | % | N | % | N | % | OR (95% CI) | p-value | Total | C | I | C | I | HR* | p-value |
ISCHEMIC AND THROMBOTIC EVENTS |
146 | 24 | 64 | 20 | 82 | 28 | 0.67 (0.46–0.98) | .04 | 31 | 16 | 23 | 23 | 33 | 0.67 | .02 |
Acute MI | 47 | 8 | 23 | 7 | 24 | 8 | 0.89 (0.49–1.62) | .70 | 10 | 5 | 6 | 8 | 9 | 0.86 | .60 |
Ischemic Heart Disease | 49 | 8 | 18 | 6 | 31 | 11 | 0.5 (0.27–0.93) | .03 | 10 | 5 | 9 | 7 | 13 | 0.50 | .02 |
Thrombosis (severe) | 82 | 14 | 37 | 12 | 45 | 15 | 0.76 (0.47–1.21) | .25 | 18 | 9 | 12 | 14 | 18 | 0.75 | .20 |
ENDOCRINE | 259 | 43 | 138 | 44 | 121 | 41 | 1.15 (0.83–1.6) | .41 | 52 | 44 | 41 | 51 | 48 | 1.03 | .81 |
Diabetes | 117 | 19 | 62 | 20 | 55 | 19 | 1.13 (0.75–1.72) | .55 | 24 | 18 | 18 | 23 | 22 | 1.09 | .67 |
Diabetes with Sequelae | 52 | 9 | 26 | 8 | 26 | 9 | 0.97 (0.54–1.72) | .91 | 12 | 7 | 8 | 9 | 10 | 0.95 | .84 |
Hypercholesterolemia | 194 | 32 | 99 | 32 | 95 | 32 | 0.97 (0.69–1.37) | .89 | 40 | 30 | 31 | 37 | 38 | .94 | .66 |
Obesity | 42 | 7 | 25 | 8 | 17 | 6 | 1.44 (0.76–2.73) | .27 | 9 | 7 | 5 | 9 | 7 | 1.35 | .34 |
Osteoporosis | 130 | 21 | 73 | 23 | 57 | 19 | 1.25 (0.84–1.85) | .28 | 26 | 21 | 18 | 26 | 23 | 1.13 | .49 |
Skeletal related event and fracture |
96 | 16 | 53 | 17 | 43 | 15 | 1.18 (0.76–1.85) | .45 | 20 | 12 | 11 | 20 | 18 | 1.12 | .58 |
All Bone | 176 | 29 | 97 | 31 | 79 | 27 | 1.22 (0.85–1.75) | .28 | 35 | 27 | 24 | 36 | 32 | 1.11 | .52 |
SEXUAL DYSFUNCTION | |||||||||||||||
Organic | 35 | 6 | 20 | 6 | 15 | 5 | 1.29 (0.65–2.58) | .47 | 7 | 6 | 5 | 8 | 6 | 1.25 | .52 |
MISCELLANEOUS | |||||||||||||||
Depression Acute Kidney Injury |
83 117 |
14 19 |
43 60 |
14 19 |
40 57 |
14 19 |
0.99 (0.62–1.58) 1.01 (0.67–1.52) |
.97 .97 |
18 31 |
11 13 |
12 14 |
15 21 |
15 21 |
0.97 0.98 |
.87 .90 |
Regression analyses were conducted separately for each adverse event type in multivariable regression models, adjusting for demographic and stratification factors as covariates as specified in the Methods. In addition to the events listed in the table, patients on the continuous ADT arm had higher observed rates of dementia (overall percent = 5%; OR = 2.65, p=.02; overall cumulative incidence = 7%, hazard ratio = 2.51, p=.03).
Represents the subdistribution hazard ratios based on competing risk regression analyses.