Figure 1.

Adapted from Calabrese et al. (2015b) Figure 6, with permission. (A) Directionally colored diffusion MRI tractography (DT) of the dentatorubrothalamic tract (DRT), which connects the dentate nucleus of the cerebellum, red nucleus, ventral intermediate thalamus, and motor cortex. Note the absence of a midline crossing in the midbrain, which is a limitation of the diffusion tensor imaging (DTI) technique. (B) Tract proximity analysis (TPA). Distances between the DRT (blue) and the deep brain stimulation (DBS) electrode (red) are compared with treatment outcomes. (C) Tract activation modeling. Fiber tracts (yellow) are generated from a region of interest surrounding the DBS contacts (red). (D) Direct tract targeting (DTT). The DT model of the DRT (red) is used for preoperative DBS electrode targeting.