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. 2016 May 2;27(Suppl 1):i4–i10. doi: 10.1093/annonc/mdw083

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© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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Figure 4. — Identification of FGF18 as a gene with high prognostic capacities in high-grade advanced-stage papillary serous ovarian tumors. (A) The Kaplan–Meier analysis of FGF18 expression in patients in three independent sets of serous ovarian cancer samples (Mok 2009, Spentzos 2004, and TCGA Project 2011) linking FGF18 with poor prognosis. (B) Oncogenic effects of FGF18 on ovarian cancer cells. (B) In vitro FGF18 overexpression stimulates migration and invasion in OVCA429 and A224 cells. (C) In vivo with ectopic FGF18 overexpression promoting tumorigenicity of ovarian cancer cells s.c. inoculated in SCID mice (five mice in each group; triangles, RFP-overexpressing cells; circles, FGF18-overexpressing cells). Adapted from Wei et al. [40].