Table 3.
Performance parameters of MTBDRplus v2 by Study Site
| Resistance Smear Status | Isolates | Sensitivity % | Specificity % | |
|---|---|---|---|---|
| India | RIF | 438 | 98.0 (95.8, 99.1) | 98.8 (92.5, 99.9) |
|
| ||||
| AFB+ | 422 | 98.0 (95.7, 99.1) | 98.7 (91.9, 99.9) | |
| AFB− | 16 | 100.0 (62.9, 100.0) | 100.0 (56.1, 100.0) | |
|
| ||||
| INH | 433 | 97.3 (94.9, 98.6) | 100.0 (93.3, 100.0) | |
|
| ||||
| AFB+ | 418 | 97.5 (95.1, 98.9) | 100.0 (92.9, 100.0) | |
| AFB− | 15 | 90.9 (57.1, 99.5) | 100.0 (39.6, 100.0) | |
|
| ||||
| MDR-TB | 426 | 96.2 (93.4, 97.9) | 98.8 (92.5, 99.9) | |
|
| ||||
| AFB+ | 411 | 96.4 (93.6, 98.0) | 98.7 (92.0, 99.9) | |
| AFB− | 15 | 88.9 (50.7, 99.4) | 100.0 (51.7, 100.0) | |
|
| ||||
| Moldova | RIF | 204 | 97.0 (90.9, 99.2) | 98.1 (92.5, 99.7) |
|
| ||||
| AFB+ | 166 | 98.7 (92.0, 99.9) | 97.8 (91.4, 99.6) | |
| AFB− | 38 | 91.7 (71.5, 98.5) | 100.0 (73.2, 100.0) | |
|
| ||||
| INH | 193 | 92.7 (85.7, 96.6) | 100.0 (94.5, 100.0) | |
|
| ||||
| AFB+ | 161 | 94.4 (86.8, 97.9) | 100.0 (93.7, 100.0) | |
| AFB− | 32 | 85.7 (62.6, 96.2) | 100.0 (67.9, 100.0) | |
|
| ||||
| MDR-TB | 190 | 94.5 (87.1, 98.0) | 99.0 (93.7, 99.9) | |
|
| ||||
| AFB+ | 158 | 98.6 (91.5, 99.9) | 98.8 (92.8, 99.9) | |
| AFB− | 32 | 78.9 (53.9, 93.0) | 100.0 (71.7, 100.0) | |
|
| ||||
| South Africa | RIF | 167 | 72.2 (49.6, 88.4) | 97.2 (92.6, 99.1) |
|
| ||||
| AFB+ | 124 | 75.0 (50.6, 90.4) | 99.0 (94.0, 99.9) | |
| AFB− | 43 | 50.0 (2.7, 97.3) | 92.7 (79.0, 98.1) | |
|
| ||||
| INH | 164 | 61.8 (43.6, 77.3) | 99.2 (95.2, 100.0) | |
|
| ||||
| AFB+ | 120 | 64.3 (44.1, 80.7) | 100.0 (95.0, 100.0) | |
| AFB− | 44 | 50.0 (13.9, 86.1) | 97.4 (84.6, 99.9) | |
|
| ||||
| MDR-TB | 159 | 77.8 (51.9, 92.6) | 99.3 (95.5, 100.0) | |
|
| ||||
| AFB+ | 117 | 76.5 (49.8, 92.2) | 100.0 (95.4, 100.0) | |
| AFB− | 42 | 100.0 (5.5 100.0) | 97.6 (85.6, 99.9) | |