Table 2.

Effects on monoamine neurotransmitters and their metabolites of the rat brain after administration of P. pulchellum alkaloids (20 mg/kg).

	Control (n = 8) (ng/g tissue)	Treated (n = 8) (ng/g tissue)
5-HT (35.01%)	50.53 ± 7.53	32.84 ± 5.21∗
5-HIAA (53.45%)	47.56 ± 6.13	22.14 ± 6.48∗∗
Dopamine (54.55%)	69.20 ± 12.51	31.45 ± 16.61∗∗
DOPAC (35.54%)	168.45 ± 18.63	108.58 ± 9.21∗∗

Results are mean ± SEM (standard error of the mean). Statistical significance:  ^∗ P < 0.05 and ^∗∗ P < 0.01 compared with control (Student's t-test).