Table 2.
Pooled analyses on the association of LEPR gene polymorphisms with T2DM.
| Polymorphism | Cases/controls | Genetic model | OR (95% CI) | P value | I 2 (%) | P Q |
|---|---|---|---|---|---|---|
| p.Arg223Gln (R223Q) |
3649/2381 | Allele | 1.27 [1.13, 1.42] | <0.0001 | 38 | 0.13 |
| Dominant | 1.19 [1.05, 1.35] | 0.007 | 28 | 0.13 | ||
| Homozygote | 1.82 [1.38, 2.39] | <0.0001 | 17 | 0.22 | ||
| Recessive | 1.75 [1.35, 2.28] | <0.0001 | 37 | 0.29 | ||
|
| ||||||
| p.Arg109Lys (R109K) |
3536/2268 | Allele | 1.02 [0.92, 1.12] | 0.73 | 0 | 0.45 |
| Dominant | 1.02 [0.86, 1.20] | 0.86 | 27 | 0.23 | ||
| Homozygote | 1.15 [0.81, 1.65] | 0.44 | 0 | 0.8 | ||
| Recessive | 1.17 [0.82, 1.66] | 0.39 | 0 | 0.84 | ||
|
| ||||||
| p.Lys656Asn (K656N) |
2018/1641 | Allele | 1.08 [0.91, 1.30] | 0.38 | 20 | 0.26 |
| Dominant | 1.09 [0.90, 1.33] | 0.36 | 10 | 0.35 | ||
| Homozygote | 0.79 [0.38, 1.65] | 0.53 | 0 | 0.79 | ||
| Recessive | 0.78 [0.38, 1.61] | 0.5 | 0 | 0.83 | ||
|
| ||||||
| p.Pro1019Pro (P1019P) |
753/767 | Allele | 1.49 [0.89, 2.50] | 0.13 | 78 | 0.03 |
| Dominant | 1.28 [0.84, 1.96] | 0.25 | 67 | 0.05 | ||
| Homozygote | 1.86 [1.14, 3.02] | 0.01 | 10 | 0.29 | ||
| Recessive | 1.75 [1.12, 2.72] | 0.01 | 1 | 0.31 | ||
|
| ||||||
| 3′UTR ins/del |
544/690 | Allele | 0.69 [0.55, 0.86] | 0.001 | 0 | 0.5 |
| Dominant | 0.71 [0.55, 0.92] | 0.008 | 34 | 0.22 | ||
| Homozygote | 0.75 [0.05, 11.7] | 0.84 | 66 | 0.08 | ||
| Recessive | 0.35 [0.16, 0.76] | 0.92 | 69 | 0.07 | ||