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. 2016 May 2;7:636. doi: 10.3389/fmicb.2016.00636

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Copyright © 2016 Zhang, Chen, Hao, Su, Xue, Yan, Zhu and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed scheme illustrating the toxicity and adaptive-response pathways of LSJC7 to As(V) stress. (1) As(V) influx pumps was down-regulation; (2) ArsC converted As(V) to As(III); (3) ArsB extruded As(III); (4) Arsenic induced ROS and NO generation; (5) ROS induced Fe–S clusters biogenesis and iron recruiting; (6) Endogenous NO up-regulated nsrR and hmp; (7) Genes related to nitrate respiration and TCA cycle; (8) NO induced Iron–sulfur cluster repair and suppressed Fenton reaction; (9) SoxRS activated by NO might modulate DNA and protein repair; (10) Peroxiredoxins were modulated.