Table 5.

Logistic regression analysis of association between GI events and type of osteoporosis treatment initiated

Effect	Initiated bisphosphonates vs. initiated non-bisphosphonates
Post-index GI event (ref: no post-index GI event)	Odds ratio	95 % CI	p value
Among patients without pre-index GI problems	0.591	(0.55, 0.64)	<0.0001
Among patients with pre-index GI problems	0.631	(0.58, 0.68)	<0.0001
Age group
65–74 vs. 55–64	1.393	(1.00, 1.95)	0.0603
75–84 vs. 55–64	1.576	(1.18, 2.01)	<0.0001
85+ vs. 55–64	1.154	(0.77, 1.75)	0.2332
Pre-index medication use
Gastro-protective agents	1.693	(1.21, 2.38)	<0.0001
NSAIDs	1.094	(0.86, 1.39)	0.3443
Glucocorticoids	1.066	(0.78, 1.46)	0.4532
Charlson comorbidity index score	1.004	(0.88, 1.15)	0.3594

CI confidence interval