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. 2016 May 2;6:18. doi: 10.1186/s13395-016-0089-3

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© Jenkins et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Mechanism of in vivo Fn downregulation at the MTJ. Upper panel: normal scenario—laminin is polymerized at the MTJ, Mmp11 expression is localized at the MTJ, and Fn is subsequently downregulated. Lower panel: scenario when laminin deposition/organization is disrupted—Mmp11 expression is reduced, Mmp11 localization is abnormal, and Fn perdures at the MTJ