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. 2016 Apr 30;15:31. doi: 10.1186/s12943-016-0514-6

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© Nojima et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Association between methylation levels of microRNA-coding regions and respective microRNA expression. a. Visualization of a statistical model relating microRNA expression with respective methylation change, stratified by relative location from gene and CpG island. The effect of methylation change was estimated from regression coefficients for the relative methylation change. Methylation and expression levels in background tissues were also included as a covariate. Darkest line: CpG island, darker: Shore, lighter: Shelf, lightest: Non-island. b. Visualization of a statistical model relating average clustered microRNA expression with respective methylation change (cluster-level analysis). The effect of methylation change was estimated from regression coefficients for the relative methylation change. Methylation and expression levels in background tissues were also included as a covariate. Dark green line: Clustered miRNA methylation, blue dotted: background expression of clustered miRNAs. c. Box plots for correlation between clustered microRNA expression and methylation change. d. Scatter plots for correlation between average expression and methylation of microRNA cluster 2p16.1 and 7q32.2. Gray: 2p16.1, green: 7q32.2. e. Relative methylation change (backgroun. Scatter plots and associated regression regarding correlation between clustered microRNA expression and methylation stratified by quartile of microRNA expression in background tissues. Circles were painted in different colors according to miRNA clusters