Table 3.

Sensitivity, specificity, positive and negative predictive values (PPV and NPV) and best cut-off point for scores of the 10-item and 5-item MADRS

10-item MADRS
Cut-off	5/6	6/7	7/8	8/9	9/10	10/11	11/12	12/13	13/14 a	14/15	15/16
Sensitivity	0.92	0.92	0.92	0.90	0.87	0.85	0.85	0.85	0.85	0.77	0.69
Specificity	0.64	0.66	0.69	0.70	0.74	0.76	0.77	0.81	0.81	0.83	0.84
PPV	0.52	0.56	0.56	0.57	0.59	0.60	0.62	0.69	0.70	0.72	0.72
NPV	0.95	0.95	0.95	0.94	0.93	0.92	0.92	0.91	0.91	0.86	0.82
γ	0.56	0.58	0.61	0.62	0.62	0.61	0.62	0.66	0.66	0.60	0.53
5-item MADRS
Cut-off	5/6	6/7	7/8	8/9	9/10	10/11 a	11/12	12/13	13/14	14/15	15/16
Sensitivity	0.88	0.88	0.85	0.81	0.81	0.81	0.69	0.65	0.58	0.58	0.46
Specificity	0.75	0.76	0.81	0.85	0.86	0.87	0.88	0.90	0.90	0.90	0.93
PPV	0.57	0.56	0.61	0.70	0.71	0.75	0.74	0.78	0.76	0.76	0.81
NPV	0.71	0.94	0.94	0.91	0.91	0.90	0.85	0.82	0.79	0.79	0.72
γ	0.63	0.64	0.66	0.66	0.67	0.68	0.57	0.55	0.48	0.48	0.47

γ Youden’s index = (sensitivity + specificity) - 1

^aMaximum trade-off between sensitivity and specificity

Bold-data: MADRS' threshold scores