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. 2016 Apr 6;6(4):150272. doi: 10.1098/rsob.150272

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© 2016 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — The ANGPTL3-4-8 model. ANGPTL8, ANGPTL3 and ANGPTL4 regulate triglyceride (TG) trafficking by inhibiting lipoprotein lipase, in a tissue-specific manner, under different nutritional statuses. The level of ANGPTL3 is stable, regardless of nutritional status, but it requires activation by ANGPTL8. Fasting induces ANGPTL4, which inhibits LPL in WAT to direct circulating TG to cardiac and skeletal muscles for oxidation (a); conversely, feeding induces ANGPTL8, activating the ANGPTL8–ANGPTL3 pathway, which inhibits LPL in cardiac and skeletal muscles to direct circulating TG to WAT for storage (b).