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. 2016 Apr 6;6(4):160034. doi: 10.1098/rsob.160034

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© 2016 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 2. — MPODD is localized to the parasite mitochondrion and is important for zygote to ookinete conversion. (a) C-terminally mCherry tagging of MPODD reveals expression in all life cycle stages and co-localization with MitoTracker Green-FM. MGS, midgut sporozoite. SGS, salivary gland sporozoite. (b) mpodd(−) parasites display comparable blood-stage growth rates. (c) mpodd(−) parasites do not form oocysts in the mosquito midgut, whereas complementation of the knockout with Pb MPODD (mpodd(−);mpodd^PBANKA) restores infectivity. Mean with standard error indicated by the horizontal lines. The average wt anka oocyst load per infected midgut was not significantly different from mpodd(−);mpodd^PBANKA infected mosquitoes. (d) mpodd(−) parasites do not develop into fully mature ookinetes and arrest at the retort stage. Scale bar: 5 µm.