Table 1.
Frequencies (percentagesa) of breast cancer triple subtypes and patient demographics, Atlanta, GA, 1990–1992
| TN (n = 135) |
ER−PR−HER2+ (n = 33) |
ER/PR+HER2+ (n = 36) |
ER/PR+HER2− (n = 272) |
Controls (n = 913) |
|
|---|---|---|---|---|---|
| Race | |||||
| Black | 56 (49.1) | 12 (39.5) | 7 (25.7) | 41 (21.3) | 251 (27.5) |
| White | 79 (50.9) | 21 (60.5) | 29 (74.3) | 231(78.7) | 662 (72.5) |
| Age at diagnosis*, y | |||||
| 20–39 | 51 (34.1) | 9 (23.3) | 11 (27.7) | 53 (17.8) | 205 (22.5) |
| 40–49 | 57 (46.3) | 17 (55.4) | 20 (59.8) | 146 (55.2) | 469 (51.4) |
| 50–54 | 27 (19.6) | 7 (21.3) | 5 (12.6) | 73 (27.0) | 239 (26.2) |
| Stage | |||||
| I | 38 (28.2) | 9 (27.4) | 13 (37.4) | 131 (46.2) | N/A |
| IIA | 46 (36.3) | 5 (14.8) | 13 (36.4) | 69 (25.6) | N/A |
| IIB | 27 (18.9) | 10 (29.0) | 8 (20.4) | 37 (14.2) | N/A |
| III/IV | 22 (16.6) | 9 (28.7) | 2 (5.7) | 35 (14.0) | N/A |
| Education* | |||||
| <College grad | 86 (64.5) | 26 (79.1) | 22 (63.5) | 145 (54.1) | 581 (63.6) |
| College grad+ | 49 (35.5) | 7 (20.9) | 14 (36.5) | 127 (45.9) | 332 (36.4) |
| Poverty index* (SES) | |||||
| ≤200 (low) | 32 (26.6) | 11 (33.0) | 3 (9.0) | 31 (13.4) | 132 (15.0) |
| 201–700 (middle) | 66 (49.5) | 14 (43.6) | 18 (53.6) | 154 (57.3) | 537 (60.9) |
| >700 (high) | 34 (24.0) | 8 (23.5) | 13 (37.4) | 79 (29.3) | 213 (24.2) |
| Insurance status*, b | |||||
| Private | 110 (79.9) | 25 (75.3) | 32 (88.7) | 254 (92.4) | – |
| Public/none | 25 (20.1) | 8 (24.7) | 4 (11.3) | 18 (7.6) | – |
| Smoking status | |||||
| Never | 67 (49.9) | 12 (37.6) | 13 (40.5) | 127 (47.2) | 450 (49.3) |
| Former | 53 (38.6) | 11 (31.3) | 21 (53.9) | 110 (40.0) | 266 (29.1) |
| Current | 15 (11.5) | 10 (31.1) | 2 (5.6) | 35 (12.8) | 197 (21.6) |
| Alcohol*, drinks/week | |||||
| Never | 55 (43.5) | 9 (26.2) | 12 (37.8) | 73 (28.8) | 381 (41.8) |
| <7 | 58 (41.8) | 17 (49.5) | 17 (45.1) | 145 (51.9) | 397 (43.5) |
| 7+ | 22 (14.8) | 7 (24.2) | 7 (17.2) | 52 (19.3) | 134 (14.7) |
| Age at menarche*, y | |||||
| <12 | 43 (32.9) | 10 (32.5) | 8 (21.2) | 66 (23.7) | 201 (22.1) |
| 12+ | 91 (67.1) | 23 (67.5) | 28 (78.8) | 206 (76.3) | 708 (77.9) |
| Age at first birth, y | |||||
| Nulliparous | 30 (21.5) | 3 (9.6) | 12 (31.4) | 60 (22.1) | 155 (17.0) |
| <18 | 13 (11.4) | 5 (16.3) | 2 (5.0) | 7 (2.9) | 89 (9.8) |
| 18+ | 92 (67.1) | 25 (74.1) | 22 (63.5) | 205 (75.1) | 668 (73.3) |
| No. full-term births* | |||||
| 0 | 30 (21.5) | 3 (9.6) | 12 (31.4) | 60 (22.1) | 155 (17.0) |
| 1–3 | 89 (66.5) | 27 (82.2) | 20 (58.3) | 197 (72.5) | 630 (69.0) |
| ≥4 | 16 (12.0) | 3 (8.1) | 4 (10.3) | 15 (5.5) | 128 (14.0) |
| Recency of birth, y | |||||
| Nulliparous | 30 (21.5) | 3 (9.6) | 12 (32.3) | 60 (22.1) | 155 (17.1) |
| ≤5 | 20 (14.7) | 5 (12.9) | 4 (10.2) | 14 (4.6) | 78 (8.6) |
| >5 | 85 (63.8) | 25 (77.4) | 19 (57.5) | 198 (73.4) | 674 (74.3) |
| Breastfeeding | |||||
| Never (nvr pg/≤2 weeks) | 85 (65.1) | 21 (63.1) | 25 (71.2) | 162 (60.4) | 534 (58.5) |
| Ever (>2 weeks) | 50 (35.0) | 12 (36.9) | 11 (28.8) | 110 (39.6) | 379 (41.5) |
| BMI (kg/m2) at interview* | |||||
| Underweight/normal (<25) | 54 (38.2) | 15 (44.7) | 23 (65.9) | 171 (60.0) | 408 (46.2) |
| Overweight (25.0–29.9) | 39 (28.5) | 11 (33.5) | 7 (17.6) | 57 (21.2) | 248 (28.1) |
| Obese (30+) | 41 (33.3) | 7 (21.8) | 6 (16.5) | 43 (18.9) | 227 (25.7) |
| Physical activity- year before interview (RU) | |||||
| <13.54 (below median) | 68 (51.5) | 19 (57.4) | 14 (42.7) | 139 (52.8) | 363 (40.4) |
| ≥13.54 (median+) | 67 (48.5) | 14 (42.7) | 22 (57.3) | 133 (47.2) | 536 (59.6) |
*
Mantel–Haenszel Chi-square p-value <0.05
a
All percentages are weighted column percentages
b
Insurance status was obtained from case medical records and follow-up interviews and is unavailable for controls
ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor; TN, triple negative