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PMMTM exposure inhibits endothelium-dependent vasodilation in skeletal muscle arterioles in vivo. (A) Intraluminal infusion of A23187 (a calcium ionophore) led to a dose-dependent increase in arteriolar diameter. (B) Data from Panel (A) were analyzed using% change from control diameter (see Methods) to illustrate the dramatic difference between dilation in sham vs. PMMTM-exposed arterioles. *p < 0.05 vs. sham, #p < 0.05 vs. 0 PSI sham, †p < 0.05 vs. 10 PSI sham.
