Table 3.

Sign tests of directional effects among 94 genome-wide significant associations with schizophrenia (P<5×10⁻⁸) and the top 231 associations (P<1×10⁻⁶).

Brain region	P threshold	N same direction	Proportion	P
Intracranial volume	<5×10−8	49	0.52	0.379
Caudate nucleus	<5×10−8	47	0.50	0.541
Hippocampus	<5×10−8	46	0.49	0.621
Nucleus accumbens	<5×10−8	48	0.51	0.459
Pallidum	<5×10−8	51	0.54	0.235
Putamen	<5×10−8	52	0.55	0.177
Thalamus	<5×10−8	49	0.52	0.379
Amygdala	<5×10−8	49	0.52	0.379
Intracranial volume	<1×10−6	121	0.52	0.255
Caudate nucleus	<1×10−6	113	0.49	0.653
Hippocampus	<1×10−6	105	0.45	0.926
Nucleus accumbens	<1×10−6	109	0.47	0.821
Pallidum	<1×10−6	117	0.51	0.448
Putamen	<1×10−6	115	0.50	0.552
Thalamus	<1×10−6	115	0.50	0.552
Amygdala	<1×10−6	109	0.47	0.821

The expected proportion under the null is 0.5.