Fig. 7.

Proposed model of endocytosis and recycling pathways of CTR1. Under conditions of elevated extracellular Cu, CTR1 is endocytosed from the plasma membrane by a clathrin- and dynamin-mediated (CME) process. Internalized CTR1 is then localized in early endosomes and, when Cu is removed from the external media, it is transported back to the plasma membrane in a Rab11-dependent recycling pathway. CIE, clathrin-independent pathway; EE, early endosome; Late endo, late endosome; Lyso, lysosome; RE, recycling endosome.