Fig. 7.

FAK activation mediates VCAM-1 expression and RSK activation in vivo. Aortic roots from FAK-WT (Cre+) and FAK-KD (Cre+) mice were stained for (A) VCAM-1 (red) or (B) P-S380 RSK (red) and co-stained for endothelial cells (vWF, green) and DAPI. VCAM-1 or P-S380 RSK positive staining in the endothelium was quantified at three separate sites along the aortic root 50 μM away from each other (n=5 per group). Results are mean±s.e.m. *P<0.05 (compared to FAK-WT) using two-tailed Student's t-test. Scale bars: 50 μm. (C) Model of oxLDL-induced NF-kB activation through FAK-dependent RSK signaling.