Haploinsufficiency of Rictor, but not Akt, significantly decreases male life span. (A) Kaplan–Meier plots showing life spans of male and female mice heterozygous for Rictor. (B) Kaplan–Meier survival plots showing life spans of mice heterozygous for Akt. (Panel A from Lamming et al. 2014b; reprinted, with permission, from the author. Panel B from Nojima et al. 2013; adapted, with permission, from the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium.)