Figure 3.

Mechanisms to direct the differentiation of endogenous neural stem/progenitor cells (NSPCs). Shown are several experimental strategies to enhance neural subtype specific differentiation (e.g., through modulating WNT signaling) or to direct the fate of newborn cells from a neuronal toward the glial lineage (e.g., through ascl1 overexpression in hippocampal NSPCs; shown in the left inset). NSC, Neural stem cell; DG, dentate gyrus; SVZ, subventricular zone; RMS, rostral migratory stream; OB, olfactory bulb. (Figure courtesy of Dr. S.M.G. Braun, Brain Research Institute, Zurich, Switzerland.)