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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Curr Opin Chem Eng. 2016 Feb;11:94–105. doi: 10.1016/j.coche.2016.01.012

Figure 1. Generating a three-dimensional tumor model.

Figure 1

Cancer cells, supporting stromal cells, biomaterial scaffold, molecular and physical signals are used in an integrated way to bioengineer in vitro models of human cancer. Inset: illustration of a typical tumor microenvironment with the supporting cells, ECM, and signaling molecules; reproduced with permission from [2].