Table 4. Association between 24h urinary potassium excretion and 30% decline in eGFR and death.
| 24h urinary potassium excretion | |||||
|---|---|---|---|---|---|
| Variable | <1.5 g/day | 1.5–2.0 g/day | 2.0–2.5 g/day | 2.5–3.0 g/day | >3.0 g/day |
| Number of patients | 242 | 349 | 301 | 194 | 144 |
| Follow up duration, years | 5.16 (2.31) | 5.44 (2.32) | 5.69 (2.29) | 5.49 (2.29) | 5.59 (2.08) |
| 30% decline in eGFR or death, n (%) | 36 (14.8) | 41 (11.7) | 24 (7.9) | 12 (6.1) | 17 (11.8) |
| Death, n | 2 | 0 | 3 | 0 | 1 |
| Analysis, HR (95% CI) | |||||
| Univariate analysis | 1.00 | 0.71 (0.45–1.11) | 0.44 (0.26–0.74) | 0.36 (0.19–0.70) | 0.70 (0.39–1.26) |
| Multivariate analysis | 1.00 | 0.69 (0.43–1.10) | 0.49 (0.28–0.84) | 0.44 (0.22–0.87) | 0.71 (0.37–1.34) |
| Multivariate analysis excluding A | 1.00 | 0.63 (0.33–1.20) | 0.33 (0.15–0.72) | 0.27 (0.09–0.76) | 0.62 (0.24–1.58) |
| Multivariate analysis excluding A or B | 1.00 | 0.63 (0.27–1.49) | 0.28 (0.10–0.77) | 0.15 (0.03–0.74) | 0.73 (0.22–2.40) |
| Multivariate analysis excluding C | 1.00 | 0.49 (0.17–1.40) | 1.03 (0.35–3.06) | 0.86 (0.25–2.94) | 1.66 (0.42–6.54) |
Categorical variables are expressed as number (%) and continuous variables are expressed as mean (SD).
Multivariate analysis adjusted for age, sex, body mass index, history of CVD, diabetic retinopathy, blood pressure, HbA1c, eGFR, uric acid, total cholesterol, high density lipoprotein, 24h urinary albumin excretion and 24h urinary sodium excretion.
A: eGFR < 60 ml/min/1.73m2 or 24h urinary albumin excretion > 30 mg/day at baseline
B: A and history of CVD at baseline
C: eGFR > 60 ml/min/1.73m2
eGFR; estimated glomerular filtration rate; HR, hazard ratio, CI, confidence interval; CVD, cardiovascular disease; HbA1c, glycated hemoglobin