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A TH17 signature characterizes CD4+ T cells of the healthy nasal mucosa. A, Representative IL-13/IL-17 staining in polyp and healthy nasal mucosa biopsy specimen (NM bx) CD4+ cells (n = 3). B, IL-17 expression in explant culture supernatants (n = 7, mean + SEM; Mann-Whitney test. C, Heat map of TH17 genes in NM bx versus blood CD4+ cells (n = 3). D, IL-17 coexpression with IFN-γ/IL-22 in blood versus polyp CD4+ cells (n = 6; Wilcoxon matched-pairs signed-rank test). *P < .05.
