Table I.
TCR Vβ repertoire analysis of IL-17RB+/− cells
| Patient ID |
HKP020 |
HKP023 |
HKP026 |
HKP036 |
||||
|---|---|---|---|---|---|---|---|---|
| Cell population | IL-17RB+ | IL-17RB− | IL-17RB+ | IL-17RB− | IL-17RB+ | IL-17RB− | IL-17RB+ | IL-17RB− |
| Total clones (productive) | 4,871 | 1,146 | 969 | 3,801 | 1,896 | 443,183 | 2,435 | 47,486 |
| Unique clones (no.) | 33 | 91 | 28 | 97 | 55 | 6,475 | 113 | 1,759 |
| Shared clones | 0 | 1 | 25 | 11 | ||||
| Common clones | ||||||||
| CASSLNTGYEQYF | + | − | + | + | + | − | − | − |
| CASSYPGEAFF | + | − | + | − | − | − | + | − |
Numbers of unique TCR clones present in sorted polyp-derived CD4+IL-17RB+ and CD4+IL-17RB− populations analyzed by using the immunoSEQ assay are shown (n = 4 separate donors). Amino acid sequences represent CDR3 regions of 2 common clones identified within the IL-17RB+ population of at least 3 of the 4 donors.