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. 2016 Apr 22;11:1643–1661. doi: 10.2147/IJN.S101030

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© 2016 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Synthetic routes of TGK (A) and T2K (B).

Abbreviations: mPEG2K-NHS, methoxy-polyethylene glycol (MW 2,000 Da) activated by N-hydroxysuccinimide; GK8, GPVGLIGK-NH₂ peptide; α-TOS, d-α-tocopheryl succinate; TCTU, O-(6-chlorobenzotriazol-1-yl)-N,N,N′,N′,-tetramethyluronium tetrafluoroborate; DMF, dimethylformamide; TEA, triethylamine; TGK, mPEG2K-GK8-α-TOS conjugate; T2K, mPEG2K-α-TOS conjugate; MW, molecular weight.