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. 2016 Apr 26;11:1687–1700. doi: 10.2147/IJN.S103332

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© 2016 Shen et al. This work is published and licensed by Dove Medical Press Limited

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Temporal in vitro release assays of various berberine formulations.

Notes: Utilizing different external experimental and simulated release media: (A) PBS, pH 7.4; (B) FBS, pH 7.4; (C) SGF, pH 1.6, and (D) SIF with 5 mM bile salts, pH 6.5, all studied at 37°C (n=5, mean ± SD).

Abbreviations: Brb, berberine; h, hours; Sol, solution; PeGMic, pure PEG-PE micelle; mMic, mixed micelle; PBS, phosphate-buffered saline solution; FBS, fetal bovine serum; SGF, simulated gastric fluid; SIF, simulated intestinal fluid; SD, standard deviation; PEG-PE, 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000].