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. 2016 Apr 26;11:1687–1700. doi: 10.2147/IJN.S103332

Figure 7.

Figure 7

Evaluation of interaction with prostate cancer cell cultures.

Notes: Epifluorescence microscopy of PC3 cell monolayers, following 4 hours of treatment with various Brb formulations: (A) blank mMic vehicle control, (B) free Brb solution, (C) simple mix of free Brb solution + blank mMic, (D) Brb-loaded mMic, all at 37°C, 5% CO2 conditions; in addition to (E) temporal analysis of LNPaC spheroid-associated fluorescence, measured 4 hours of coincubation (n=4, mean ± SE values denoted with unlike symbols (*, †, and #) are statistically different, P≤0.05).

Abbreviations: Brb, berberine; h, hours; mMic, mixed micelle.