Table 1.
Markers for BCSC characterization
| Markers | Localization | Isolation | References |
|---|---|---|---|
| ALDH1 | Cytoplasm | + | 13 |
| CD24 | Cell surface | + | 2 |
| CD44 | Cell surface | + | 2 |
| EpCAM | Cell surface | + | 42 |
| MUC1 | Cell surface | + | 76 |
| P-cadherin | Cell surface | 70, 71 | |
| N-cadherin | Cell surface | 74 | |
| CD49f | Cell surface | 42 | |
| CD29 | Cell surface | 42 | |
| CD47 | Cell surface | 42 | |
| CD133 | Cell surface | 42, 74 | |
| CD338 | Cell surface | 77 | |
| MET | Cell surface | 42, 35 | |
| HER2 | Cell surface | 42 | |
| Keratins | Cytoplasm | 79 | |
| Vimentin | Cytoplasm/cell surface | + | 58, 72, 93 |
| Sox2 | Nucleus/cytoplasm | 42 | |
| Bmi1 | Nucleus/cytoplasm | 42 | |
| p53 | Nucleus/cytoplasm | 42 | |
| GLI1 | Nucleus/cytoplasm | 78 | |
| Twist1 | Nucleus/cytoplasm | 73, 75 | |
| Akt2 | Nucleus/cytoplasm | 75, 76 | |
| Snail | Nucleus/cytoplasm | 73 | |
| Zeb1 | Nucleus/cytoplasm | 76 | |
| Tg2 | Nucleus/cytoplasm | 76 |
Note: The localization of proteins expressed in BCSCs and used for their isolation is shown.
Abbreviations: ALDH1, aldehyde dehydrogenase 1; BCSC, breast cancer stem cell; EpCAM, epithelial cell adhesion molecule; HER2, human epidermal growth factor receptor 2.