Table 3.
Subgoup analysis
| Subgroup | I2 (%) | P-value | HR (95% CI) | P-value |
|---|---|---|---|---|
| Origin of population | ||||
| White patients | 77.6 | <0.01 | 0.76 (0.63–0.92)a | 0.04 |
| Asian patients | 42.1 | 0.08 | 0.67 (0.58–0.77)b | <0.01 |
| Tumor type | ||||
| Digestive system cancers | 9.9 | 0.35 | 0.70 (0.59–0.83)b | <0.01 |
| Respiratory system cancers | 82.2 | <0.01 | 0.71 (0.59–0.85)a | <0.01 |
| Source of RNA | ||||
| Tissue | 60.3 | 0.02 | 0.68 (0.60–0.76)a | <0.01 |
| Blood | 60.9 | 0.08 | 1.25 (0.76–2.04)b | 0.38 |
| miR-126 assay | ||||
| ISH | 25.9 | 0.26 | 0.75 (0.53–1.05)b | 0.10 |
| qRT-PCR | 68.0 | <0.01 | 0.7 (0.61–0.79)a | <0.01 |
| HR | ||||
| Report | 63.2 | 0.02 | 0.69 (0.61–0.79)a | <0.01 |
| DE | 70.0 | 0.01 | 0.75 (0.54–1.05)a | 0.10 |
| Cutoff | ||||
| Median | 70.4 | <0.01 | 0.70 (0.62–0.80)a | <0.01 |
| Others | 0 | 0.42 | 0.69 (0.54–0.88)b | <0.01 |
| Multivariate analysis | ||||
| Yes | 42.9 | 0.08 | 0.72 (0.63–0.83)b | <0.01 |
| No | 75.8 | <0.01 | 0.66 (0.54–0.81)a | <0.01 |
Notes:
a
Random-effects model.
b
Fixed-effects model. P-value <0.05 was considered to be statistically significant.
Abbreviations: HR, hazard ratio; miR-126, microRNA-126; ISH, in situ hybridization; qRT-PCR, quantitative real-time polymerase chain reaction; DE, data extrapolated; CI, confidence interval.