Skip to main content
. Author manuscript; available in PMC: 2016 May 2.
Published in final edited form as: J Neurotrauma. 2011 Dec 20;29(3):539–550. doi: 10.1089/neu.2011.1976

FIG. 1.

FIG. 1

The anti-CD11d treatment reduces neutrophil infiltration into the cord at 3 days post-injury. Shown are representative photomicrographs of sections from the lesion epicenters of 1B7 and CD11d monoclonal antibody (mAb)-treated mice 3 days after spinal cord injury (SCI), immunostained with a Ly-6G antibody (A) or a Mac-1 antibody (C). Staining for neutrophils (Ly-6G) was decreased in mice treated with the CD11d mAb compared to mice treated with the control mAb (1B7). (B) The number of Ly-6G-positive cells at the lesion epicenter in CD11d mAb-treated mice (gray bars) was significantly reduced compared to control 1B7-treated mice (open bars). (D) The mean percent area of Mac-1 immunoreactivity at the lesion epicenter in CD11d mAb-treated mice (gray bars) tended to be increased compared to control 1B7-treated mice (open bars; scale bars in A and C = 100 μm, in high-power inset = 50 μm). In B and D values are means ± standard error (*p<0.05 in B significantly different from controls by two-tailed Student’s t-test, 6 animals/group; p=0.093 in D by two-way analysis of variance, 5 animals/group).