Fig. 8.

Sox9 conditional knock-out mice demonstrate increased neurofilament immunoreactivity rostral and caudal to their lesion epicenters 14 weeks post-SCI. (A) Representative photomicrographs of anti-neurofilament immunostaining from spinal cord sections approximately 0.5 mm rostral to the lesion epicenters (A) at the epicenters (B) and 0.5 mm caudal to the lesion epicenters (C) from Sox9 conditional knock-outs and controls as indicated. (D) Quantification of area of neurofilament immunoreactivity (area per area) in Sox9 conditional knock-out and control sections. Areas of neurofilament immunostaining were quantified as explained in legend to Figure 5. *Statistically significantly different from controls (P < 0.05, two-way ANOVA, Newman-Keuls post hoc test (P < 0.05); n = 9 Sox9 KO, n = 11 control). Bars = 100 μm.