Table 1.
Demographic and clinical characteristics of study participants
| Group; mean ± SD* | Statistical test (p value) | |||||
|---|---|---|---|---|---|---|
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| Characteristic | SAD, n = 20 | WBS, n = 20 | Control, n = 20 | SAD v. WSB | SAD v. control | WSB v. control |
| Age, yr | 25.05 ± 5.25 | 25.42 ± 5.3 | 25.65 ± 6.31 | t36.527 = −0.662 (0.51) | t36.724 = −0.736 (0.75) | t33.353 = 0.205 (0.84) |
| Sex, male:female | 14:6 | 11:9 | 12:8 | χ2 = 3.801 (0.15) | χ2 = 3.801 (0.15) | χ2 = 3.801 (0.15) |
| LSAS total score | 75.8 ± 14.7 | 14.3 ± 9.2 | 13.1 ± 8.6 | t32.008 = 15.827 (< 0.001) | t30.679 = 16.432 (< 0.001) | t37.810 = −0.406 (0.69) |
| STAI-Trait total score | 33.1 ± 11.4 | 19.5 ± 12.3 | 11.7 ± 7.4 | t37.751 = 3.629 (0.001) | t32.825 = 7.031 (< 0.001) | t31.285 = 1.588 (0.022) |
| STAI-State Total Score | ||||||
| Before fMRI | 32.1 ± 7.2 | 21.9 ± 14.4 | 9.6 ± 6.4) | t28.129 = 2.840 (0.008) | t37.506 = 10.334 (< 0.001) | t31.285 = −2.412 (0.002) |
| After fMRI | 24.6 ± 6.4 | 9.3 ± 8.1 | 9.4 ± 8.3 | t36.116 = 6.579 (< 0.001) | t35.767 = 6.424 (< 0.001) | t37.980 = 0.058 (0.95) |
| VAS state anxiety | ||||||
| Before fMRI | 49.2 ± 21.4 | 33.6 ± 30 | 8.3 ± 22.2 | t32.964 = 2.160 (0.038) | t19.505 = 11.940 (0.001) | t33.213 = −2.424 (0.021) |
| After fMRI | 35.4 ± 27.4 | 5 ± 9 | 7.6 ± 12.5 | t30.670 = 4.078 (0.001) | t25.196 = 4.944 (0.001) | t36.185 = 0.586 (0.56) |
| HAM–D | 5.0 ± 4.4 | 2.6 ± 3.9 | 0.95 ± 1.4 | t34.639 = 1.720 (0.94) | t20.576 = 3.856 (0.001) | t22.358 = 1.734 (0.10) |
HAM-D = Hamilton Rating Scale for Depression; LSAS = Liebowitz Social Anxiety Scale; SAD = social anxiety disorder; STAI = State-Trait Anxiety Inventory; VAS = visual analogue scale; WBS = Wlliams–Beuren syndrome.
*
Unless indicated otherwise.