Table 2.

Regions showing significant activation during the processing of emotional faces (all faces v. shapes)

		SAD, n = 20			WBS, n = 20			Healthy control, n = 20
Brain region		MNI space	Cluster size	t*	MNI space	Cluster size	t*	MNI space	Cluster size	t*
Visual cortex	R	18, −98, 2	14070	10.10	36, −96, −8	11972	6.75	30, −94, −6	25123	13.43
	L	−14, −98, 2	14070	7.38	−36, −94, −8	11972	6.88	−26, −96, −6	25123	12.26
Lateral occipital area	R	46, −78, −2	14070	5.96	—	—	—	44, −82, −6	25123	9.31
	L	—	—	—	—	—	—	—	—	—
Fusiform gyrus	R	38, −54, −24	14070	7.21	40, −48, −20	11972	4.93	40, −50, −24	25123	9.01
	L	−40, −54, −18	14070	6.35	—	—	—	−38, −54, −20	25123	9.00
Lateral temporal cortex	R	66, −16, 10†	1311†	4.31†	64, −18, −16	139	3.35	—	—	—
	L				—	—	—	—	—	—
Superior temporal gyrus	R	44, −24, 12†	1311†	2.98†	—	—	—	—	—	—
	L	−58, −32, 12†	1822†	4.04†	—	—	—	−54, −28, 10†	1101†	3.43†
Amygdala	R	28, 4, −28‡	20‡	3.34‡				16, −6, −20	342	5.03
	L	—	—	—	−20, −8, −10	79‡	4.03	−16, −4, −22	166	4.10
Prefrontal cortex	R	44, 18, 26	1667	5.18	44, 22, 34	547	4.29	48, 18, 28	1651	5.97
	L	—	—	—	−40, 24, 24	2005	4.66	−54, 20, 32	3762	6.08
Anterior cingulate cortex	R	0, 30, 32†	1304†	4.89†	12, 18, 42	197	4.51	4, −26, 54†	215†	3.05†
	L	—	—	—	—	—	—	—	—	—

FWE = family-wise error; L = left; MNI = Montreal Neurological Institute; R = right; SAD = social anxiety disorder; WBS = Wlliams–Beuren syndrome.

^*Statistics correspond to a corrected threshold p_FWE < 0.05 estimated using Monte Carlo simulations.

^†Shows deactivation.

^‡Denotes small volume correction, p_FWE < 0.05.