TABLE 1.
Baseline Characteristics of the Study Population and Numbers of Cataract Cases (Prevalent at Five Years and Incident Thereafter) among Five-Year Survivors of Childhood Cancer in the Childhood Cancer Survivor Study
| Number | Percentage (%) | Cataract cases |
||
|---|---|---|---|---|
| Total | 13,902 | 100.0 | 483 | |
| Type of first cancer | Leukemia | 4,736 | 34.1 | 275 |
| Soft tissue sarcoma | 1,187 | 8.5 | 60 | |
| Central nervous system | 1,667 | 12.0 | 48 | |
| Non-Hodgkin lymphoma | 1,059 | 7.6 | 32 | |
| Neuroblastoma | 940 | 6.8 | 20 | |
| Hodgkin lymphoma | 1,900 | 13.7 | 29 | |
| Bone sarcoma | 1,170 | 8.4 | 12 | |
| Kidney (Wilms’ tumor) | 1,243 | 8.9 | 7 | |
| Age (in years) at first cancer diagnosis | <1 | 971 | 7.0 | 27 |
| 1–<5 | 4,581 | 33.0 | 195 | |
| 5–<10 | 3,093 | 22.2 | 113 | |
| 10–<15 | 2,820 | 20.3 | 71 | |
| 15–21 | 2,437 | 17.5 | 77 | |
| Cumulative follow-up time (in years) since first cancer diagnosis |
<5 | 13,902 | 100.0 | 200 |
| 5–<15 | 13,480 | 97.0 | 162 | |
| 15–<25 | 9,988 | 74.1 | 64 | |
| 25–38 | 5,001 | 50.1 | 57 | |
| Age (in years) at end of follow-up | <15 | 1,350 | 9.7 | 237 |
| 15–<25 | 3,236 | 23.3 | 122 | |
| 25–<35 | 4,828 | 34.7 | 66 | |
| 35–58 | 4,488 | 32.3 | 58 | |
| Sex | Male | 7,462 | 53.7 | 259 |
| Female | 6,440 | 46.3 | 224 | |
| Education | 1–8 years | 2,478 | 17.8 | 107 |
| Some high school | 2,150 | 15.5 | 64 | |
| Completed high school | 5,835 | 42.0 | 189 | |
| Completed college | 2,044 | 14.7 | 79 | |
| Post-graduate | 669 | 4.8 | 15 | |
| Missing | 726 | 5.2 | 29 | |
| Body mass index | Underweight (<18.5 kg/m2) | 1,627 | 11.7 | 64 |
| Normal (18.5–<25 kg/m2) | 7,137 | 51.3 | 243 | |
| Overweight (25–<30 kg/m2) | 2,951 | 21.2 | 98 | |
| Obese class I (30–<35 kg/m2) | 960 | 6.9 | 34 | |
| Obese class II/III (≥35 kg/m2) | 432 | 3.1 | 15 | |
| Missing | 795 | 5.7 | 29 | |
| Smoking | Never | 10,063 | 72.4 | 377 |
| Current | 2,112 | 15.2 | 46 | |
| Former | 1,193 | 8.6 | 36 | |
| Missing | 534 | 3.8 | 24 | |
| Diabetes status | No | 13,355 | 96.1 | 440 |
| Yes | 249 | 1.8 | 24 | |
| Missing | 298 | 2.1 | 19 | |
| Radiotherapy | No | 5,735 | 41.3 | 84 |
| Yes | 8,167 | 58.7 | 399 | |
| Use of corticosteroids at therapy | Dexamethasone | 970 | 7.0 | 49 |
| Prednisone | 5,755 | 41.4 | 271 | |
| Hydrocortisone | 652 | 4.7 | 23 | |
| Chemotherapy drugs | Epipodophyllotoxins | 941 | 6.8 | 57 |
| Cytosine arabinoside | 3,039 | 21.9 | 205 | |
| Anthracyclines | 4,817 | 34.6 | 248 | |
| Platinum compounds | 640 | 4.6 | 25 | |
| Methotrexate | 5,545 | 39.9 | 277 | |
| Alkylating agents | 6,314 | 45.4 | 269 | |
| Bleomycin | 688 | 4.9 | 4 |