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. Author manuscript; available in PMC: 2016 Jul 12.
Published in final edited form as: Pediatr Res. 2016 Jan 12;79(5):759–765. doi: 10.1038/pr.2016.1

Figure 3. Hydrocortisone effects on alveolar simplification are dose dependent.

Figure 3

Mice exposed to 75% O2 (hyperoxia) or room air (normoxia) ± hydrocortisone (1mg HC, 5mg HC, or 10mg HC) or sterile water (vehicle) were euthanized and lungs were inflation fixed (n=5–17 per group). Hematoxylin-stained sections were imaged at 20X, and A) mean alveolar area (black columns: vehicle, gray: 1mg HC, hatched: 5mg HC, dotted: 10mg HC) and B) mean chord length (black columns: vehicle, gray: 1mg HC, hatched: 5mg HC, dotted: 10mg HC) were measured using Scion software. Data are shown as mean ± SEM, *p<0.05 vs. normoxia-vehicle, †p<0.05 vs. hyperoxia-vehicle.